Antibacterial activity and mechanism of action of a thiophenyl substituted pyrimidine derivative.
Zhiyuan FangYanan LiYuanyuan ZhengXiaomei LiYu-Jing LuSiu-Cheong YanWing-Leung WongKin-Fai ChanKwok-Yin WongNing SunPublished in: RSC advances (2019)
The issue of multidrug resistant bacteria is a worldwide health threat. To develop new antibacterial agents with new mechanisms of action is thus an urgent request to address this antibiotic resistance crisis. In the present study, a new thiophenyl-pyrimidine derivative was prepared and utilized as an effective antibacterial agent against Gram-positive strains. In the tests against MRSA and VREs, the compound showed higher antibacterial potency than that of vancomycin and methicillin. The mode of action is probably attributed to the effective inhibition of FtsZ polymerization, GTPase activity, and bacterial cell division, which cause bactericidal effects. The compound could be a potential candidate for further development as an effective antibiotic to combat drug-resistant bacteria.
Keyphrases
- drug resistant
- multidrug resistant
- gram negative
- silver nanoparticles
- methicillin resistant staphylococcus aureus
- acinetobacter baumannii
- staphylococcus aureus
- public health
- klebsiella pneumoniae
- healthcare
- escherichia coli
- anti inflammatory
- cell therapy
- mental health
- essential oil
- single cell
- stem cells
- water soluble
- pseudomonas aeruginosa
- bone marrow