Identification of Genes Related to Endoplasmic Reticulum Stress (ERS) in Chronic Obstructive Pulmonary Disease (COPD) and Clinical Validation.

Siming TaoJing JingYide Wang Feng-Sen LiHongxia Ma

Published in: International journal of chronic obstructive pulmonary disease (2023)

Four COPDERS-related key genes (STC2, APAF1, BAX, and PTPN1) were identified through bioinformatics analysis and clinical validation, and the expressions of some genes exhibited a significant correlation with the selected clinical indicators. Furthermore, hsa-miR-485-5p was identified as a potential key target in COPDERS, but its precise mechanism remains unclear.

Keyphrases

bioinformatics analysis
endoplasmic reticulum stress
induced apoptosis
genome wide
chronic obstructive pulmonary disease
gene expression
lung function
risk assessment
dna methylation
cystic fibrosis
signaling pathway
air pollution
human serum albumin