A Bench-Stable, Single-Component Precatalyst for Silyl-Heck Reactions.
Sarah B KrauseJesse R McAteeGlenn P A YapDonald A WatsonPublished in: Organic letters (2017)
Studies of the silyl-Heck reaction aimed at identifying active palladium complexes have revealed a new species that is formed in situ. This complex has been identified as the palladium iodide dimer, [(JessePhos)PdI2]2, which has been found to be a competent single-component precatalyst for the silyl-Heck reaction. This complex is easily prepared and is temperature, moisture, and air stable. Additionally, this precatalyst provides higher activity and greater reproducibility compared to previous systems.