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Cellular uptake of modified aminoglycosides.

Kaivin HadidiEzequiel WexselblattJeffrey D EskoYitzhak Tor
Published in: The Journal of antibiotics (2017)
The uptake of modified amino- and guanidino-glycosides derived from kanamycin, tobramycin and neomycin in native and mutant CHO cells is examined using confocal microscopy and flow cytometry, illustrating the significance of multivalency for mammalian cell internalization of carriers that specifically interact with cell surface heparan sulfate proteoglycans.The Journal of Antibiotics advance online publication, 1 November 2017; doi:10.1038/ja.2017.131.
Keyphrases
  • flow cytometry
  • cell surface
  • induced apoptosis
  • cell cycle arrest
  • single cell
  • social media
  • cell therapy
  • health information
  • cell death
  • stem cells
  • oxidative stress
  • bone marrow
  • wild type