Possible role of exogenous melatonin in preventing more serious COVID-19 infection in patients with type 2 diabetes mellitus.

Wagner José Martorina Almir Ribeiro Tavares Júnior

Published in: Revista da Associacao Medica Brasileira (1992) (2021)

COVID-19 infection is more severe in patients with type 2 diabetes mellitus (DM2). The severity of this viral infection is associated with an intense inflammatory activity. DM2 is a disease that also determines a greater degree of systemic inflammation. This is due to hyperglycemia, the higher prevalence of sleep disorders and also the low levels of melatonin, a substance with anti-inflammatory actions, in these patients. In this article, we suggest that exogenous melatonin may have an important anti-inflammatory role in preventing severe forms of COVID -19 in patients with DM2.

Keyphrases

anti inflammatory
end stage renal disease
coronavirus disease
sars cov
chronic kidney disease
ejection fraction
newly diagnosed
early onset
risk factors
oxidative stress
physical activity
type diabetes
glycemic control
patient reported outcomes
depressive symptoms
weight loss