Antineonatal Fc Receptor Antibody Treatment Ameliorates MOG-IgG-Associated Experimental Autoimmune Encephalomyelitis.
Jana RemlingerAdrian MadaraszKirsten GuseRobert HoepnerMaud BagnoudIvo MeliMoritz FeilMathias AbeggChristopher LiningtonAnthony ShockBabak BoroojerdiPeter KiesslingBryan SmithVolker EnzmannAndrew ChanSalmen AnkePublished in: Neurology(R) neuroimmunology & neuroinflammation (2022)
We show preserved optomotor response and ameliorated course of disease after anti-FcRn treatment in an experimental model using a monoclonal MOG-IgG to mimic MOGAD. Selectively targeting FcRn might represent a promising therapeutic approach in MOGAD.