Endothelium-derived hydrogen sulfide acts as a hyperpolarizing factor and exerts neuroprotective effects via activation of large-conductance Ca2+ -activated K+ channels.

Ji-Yue WenJie ZhangShuo ChenYe ChenYang ZhangZi-Yao MaFang ZhangWei-Ming XieYi-Fei FanJing-Si DuanZhi-Wu Chen

Published in: British journal of pharmacology (2021)

Endothelium-derived H2 S acts as EDHF and exerts neuroprotective effects via activating the BKCa channels and then inhibiting the T-type calcium channels in hippocampal neurons.

Keyphrases

nitric oxide
signaling pathway
spinal cord
spinal cord injury
protein kinase
subarachnoid hemorrhage