Identification of differential genomic DNA Methylation in the hypothalamus of pubertal rat using reduced representation Bisulfite sequencing.

Lei LuoZhiqiu YaoJing YeYuan TianChen YangXiaoxiao GaoMin SongYa LiuYunhai ZhangYunsheng LiXiaorong ZhangFugui Fang

Published in: Reproductive biology and endocrinology : RB&E (2017)

Our results demonstrate changes in DNA methylation occur in female rats from prepuberty to puberty suggestng DNA methylation may play a crucial role in the regulation of puberty onset. This study provides essential information for future studies on the role of epigenetics in the regulation of puberty.

Keyphrases

dna methylation
genome wide
gene expression
copy number
oxidative stress
single cell
healthcare