Total Synthesis and Stereochemical Assignment of Penicitide A.

Stereoselective total synthesis of marine secondary metabolite penicitide A has been accomplished for the first time following a convergent approach. The salient feature of this study includes Horner-Wadsworth-Emmons (HWE) olefination, Evans methylations, Crimmins acetate aldol reaction, and cross olefin metathesis. Our synthetic study established the stereochemistry of unassigned C-10 and C-12 centers and also disclosed the absolute configurations of C-3 and C-5 stereocenters.