ZEB1 directly inhibits GPX4 transcription contributing to ROS accumulation in breast cancer cells.

Xiao HanXianxian DuanZhanzhao LiuYaping LongChang LiuJing ZhouNing LiJunfang QinYue Wang

Published in: Breast cancer research and treatment (2021)

ZEB1 could not only regulate EMT, but also inhibit GPX4 transcription by binding to the E-box motif. It was important to note that the ZEB1/GPX4 axis had a therapeutic effect on breast cancer metabolism.

Keyphrases

epithelial mesenchymal transition
transcription factor
long non coding rna
breast cancer cells
signaling pathway
cell death
dna damage
reactive oxygen species
binding protein
young adults
breast cancer risk