The effect of NAD-299 and TCB-2 on learning and memory, hippocampal BDNF levels and amyloid plaques in Streptozotocin-induced memory deficits in male rats.

Simin AfsharSiamak ShahidiAli Haeri RohaniAlireza KomakiSara Soleimani Asl

Published in: Psychopharmacology (2018)

These findings suggest that 5-HT1AR blockade by NAD-299 and 5-HT2AR activation by TCB-2 improve cognitive dysfunction in icv-STZ-treated rats, and these drugs may potentially prevent the progression of AD.

Keyphrases

diabetic rats
oxidative stress
traumatic brain injury
working memory
drug induced
high glucose
stress induced
cerebral ischemia
newly diagnosed
blood brain barrier
diabetic nephropathy