Infiltrating and peripheral immune cell analysis in advanced gastric cancer according to the Lauren classification and its prognostic significance.

Simon PernotMagali TermeNina Radosevic-RobinFlorence CastanCécile BadoualElie MarcheteauFréderique Penault-LlorcaOlivier BoucheJaafar BennounaEric FrancoisFrancois GhiringhelliChristelle De La FouchardiereEmmanuelle SamalinJean Baptiste BachetChristophe BorgValérie BoigeThibault VoronTrevor StanburyEric TartourSophie GourgouDavid MalkaJulien Taieb

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2019)

Diffuse/mixed-type AGC has lower rates of CD8+ TILs and circulating NK cells and Tregs than the intestinal type. This "cold tumor" phenotype may be associated with a worse outcome.

Keyphrases

nk cells
machine learning
deep learning
low grade
squamous cell carcinoma
neoadjuvant chemotherapy
radiation therapy
lymph node
chemotherapy induced