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Infiltrating and peripheral immune cell analysis in advanced gastric cancer according to the Lauren classification and its prognostic significance.

Simon PernotMagali TermeNina Radosevic-RobinFlorence CastanCécile BadoualElie MarcheteauFréderique Penault-LlorcaOlivier BoucheJaafar BennounaEric FrancoisFrancois GhiringhelliChristelle De La FouchardiereEmmanuelle SamalinJean Baptiste BachetChristophe BorgValérie BoigeThibault VoronTrevor StanburyEric TartourSophie GourgouDavid MalkaJulien Taieb
Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2019)
Diffuse/mixed-type AGC has lower rates of CD8+ TILs and circulating NK cells and Tregs than the intestinal type. This "cold tumor" phenotype may be associated with a worse outcome.
Keyphrases
  • nk cells
  • machine learning
  • deep learning
  • low grade
  • squamous cell carcinoma
  • neoadjuvant chemotherapy
  • radiation therapy
  • lymph node
  • chemotherapy induced