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Self-sacrificial MOFs for ultra-long controlled release of bisphosphonate anti-osteoporotic drugs.

Maria VassakiKonstantinos E PapathanasiouChrystalleni HadjicharalambousDaphne ChandrinouPetri A TurhanenDuane Choquesillo-LazarteKonstantinos D Demadis
Published in: Chemical communications (Cambridge, England) (2020)
In this paper we report drug delivery systems that are based on phosphonate MOFs. These employ biologically-acceptable metal ions (e.g. Ca2+ and Mg2+) and several anti-osteoporosis bisphosphonate drugs (etidronate, pamidronate, alendronate and neridronate), as the organic linkers. These materials have been synthesized, structurally characterized, and studied for the self-sacrificial release (by pH-driven dissolution) of the bisphosphonate active ingredient. They exhibit variable release rates and final % release, depending on the actual structure of the metal-bisphosphonate material. Their cytotoxicity profiles match those of the active ingredients.
Keyphrases
  • bone mineral density
  • postmenopausal women
  • water soluble
  • quantum dots
  • mass spectrometry