Supplementation of Saponins from Leaves of Panax quinquefolius Mitigates Cisplatin-Evoked Cardiotoxicity via Inhibiting Oxidative Stress-Associated Inflammation and Apoptosis in Mice.
Jing-Jing XingJin-Gang HouYing LiuRuo-Bing ZhangShuang JiangShen RenYing-Ping WangQiong ShenWei LiXin-Dian LiZi WangPublished in: Antioxidants (Basel, Switzerland) (2019)
Findings from our present research clearly indicated that PQS exerted significant effects on cisplatin-induced cardiotoxicity in part by inhibition of the NF-κB activity and regulation of PI3K/Akt/apoptosis mediated signaling pathways.
Keyphrases
- pi k akt
- signaling pathway
- oxidative stress
- cell cycle arrest
- induced apoptosis
- epithelial mesenchymal transition
- diabetic rats
- cell proliferation
- dna damage
- ischemia reperfusion injury
- endoplasmic reticulum stress
- cell death
- high fat diet induced
- radiation therapy
- immune response
- type diabetes
- adipose tissue
- heat shock
- wild type