Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis.

Tom G RichardsonJuha MykkänenKatja PahkalaMika Ala-KorpelaJoshua A BellKurt TaylorJorma ViikariTerho LehtimäkiOlli RaitakariGeorge Davey Smith

Published in: International journal of epidemiology (2021)

Our findings suggest that childhood adiposity predominantly exerts its detrimental effect on adult systemic metabolism along a pathway that involves adulthood body size.

Keyphrases

childhood cancer
early life
insulin resistance
young adults
weight gain
depressive symptoms
metabolic syndrome
body mass index
african american
physical activity
skeletal muscle