Lipotoxic Hepatocyte-Derived Exosomal MicroRNA 192-5p Activates Macrophages Through Rictor/Akt/Forkhead Box Transcription Factor O1 Signaling in Nonalcoholic Fatty Liver Disease.

Xiao-Lin LiuQin PanHai-Xia CaoFeng-Zhi XinZe-Hua ZhaoRui-Xu YangJing ZengHuiping ZhouJian-Gao Fan

Published in: Hepatology (Baltimore, Md.) (2020)

Hepatocyte-derived exosomal miR-192-5p plays a critical role in the activation of proinflammatory macrophages and disease progression of NAFLD through modulating Rictor/Akt/FoxO1 signaling. Serum exosomal miR-192-5p represents a potential noninvasive biomarker and therapeutic target for nonalcoholic steatohepatitis.

Keyphrases

transcription factor
signaling pathway
cell proliferation
dna binding
liver injury
pi k akt