Prevalence of hypersensitivity reactions in various forms of mastocytosis: A pilot study of 2485 adult patients with mastocytosis collected in the ECNM registry.
Marek NiedoszytkoAleksandra GorskaKnut BrockowPatrizia BonadonnaMagdalena LangeHanneke Kluin-NelemansHanneke Oude-ElberinkVito SabatoKhalid ShoumariyehDagmar von BubnoffSabine MüllerAnja IllerhausMichael DoubekIrena Angelova-FischerOlivier HermineMichel ArockChiara ElenaLuca MalcovatiAkif Selim YavuzTanja Daniela SchugAnna Belloni FortinaVárkonyi JuditJason GotlibJens PanseVladan VucinicAndreas ReiterJuliana SchwaabMassimo TriggianiMattias MattssonChristine BreynaertJan RomantowskiRoberta ZanottiElisa OlivieriAlexander ZinkAnnick van de VenAlex StefanStephane BareteFrancesca CaroppoCecelia PerkinsVanessa KennedyDeborah ChristenMohamad JawharJohannes LuebkeRoberta ParenteKerstin LevedahlEmir HadzijusufovicKarin HartmannBoguslaw NedoszytkoWolfgang R SperrPeter ValentPublished in: Allergy (2024)
HR are mainly triggered by Hymenoptera venoms in patients with CM and ISM and by drugs in patients with advSM. Tryptase levels <90 ng/mL, mast cell bone marrow infiltration <15%, and WHO category ISM are predictors of HR. New HR occur in 4.8% of all patients within 4 years.