FGFR/RACK1 interacts with MDM2, promotes P53 degradation, and inhibits cell senescence in lung squamous cell carcinoma.

Tao ChenFei WangShupei WeiYingjie NieXiaotao ZhengYu DengXubin ZhuYuezhen DengNanshan ZhongCheng-Zhi Zhou

Published in: Cancer biology & medicine (2021)

Together, our findings revealed the regulatory roles and mechanisms of FGFR/RACK1 in cell senescence. This understanding should be important in the treatment of LSCC.

Keyphrases

single cell
squamous cell carcinoma
cell therapy
dna damage
endothelial cells
radiation therapy