The innate immune receptor Nlrp12 suppresses autoimmunity to the retina.

Ellen J LeeRuth J NapierEmily E VanceSydney J LashleyAgnieszka D TruaxJenny P TingHolly L Rosenzweig

Published in: Journal of neuroinflammation (2022)

Our data identify a combinatorial role for Nlrp12 in dampening autoimmunity of the neuroretina. These findings could provide a pathway for development of therapies for uveitis and potentially other autoinflammatory/autoimmune diseases of the CNS.

Keyphrases

innate immune
nlrp inflammasome
celiac disease
juvenile idiopathic arthritis
signaling pathway
electronic health record
ankylosing spondylitis
blood brain barrier
diabetic retinopathy
big data
optic nerve
optical coherence tomography