Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity.
Abhishek JoshiLukas Emanuel SchmidtSean A BurnapRuifang LuMelissa Victoria ChanPaul C J ArmstrongFerheen BaigClemens GutmannPeter WilleitPeter SanterTemo BarwariKonstantinos TheofilatosStefan KiechlJohann WilleitTimothy David WarnerAnthony MathurManuel MayrPublished in: Arteriosclerosis, thrombosis, and vascular biology (2021)
Leukocyte-to-platelet protein transfer may occur in a thromboinflammatory environment such as STEMI. Plasma S100A8/A9 was negatively associated with platelet reactivity. These findings highlight neutrophils as potential modifiers for thrombotic therapies in coronary artery disease.