DOPAMINE D4 RECEPTOR DOWN-REGULATES RENAL SODIUM CHLORIDE COTRANSPORTER VIA UBIQUITINATION-ASSOCIATED LYSOSOME DEGRADATION.
Mingzhuo ZhangMingda LiuZhiyun RenWeiwan WangKiran UpadhyayLaureano Asico AsicoInes ArmandoYutao JiaPing WangYing XueXiaoyan WangPublished in: bioRxiv : the preprint server for biology (2024)
Our data demonstrates that D4R downregulates NCC by promoting USP48-associated deubiquitination and subsequent internalization, lysosome relocation and degradation.