KLF11 is an independent negative prognostic factor for breast cancer from a cohort study and induces proliferation and inhibits apoptosis in vitro.

Lili LinKristina PfenderNina DitschChristina KuhnMartina RahmehLin PengElisa SchmoeckelDoris MayrFabian TrillschSven MahnerMirjana KesslerUdo JeschkeAnna Hester

Published in: Breast cancer (Tokyo, Japan) (2023)

Our study indicated that targeting KLF11 is an interesting therapeutic concept and further research could lead to a new therapeutic improvement in BC, especially in highly aggressive molecular subtypes.

Keyphrases

prognostic factors
transcription factor
oxidative stress
endoplasmic reticulum stress
signaling pathway
cancer therapy
childhood cancer
cell proliferation