Combinations of ATR, Chk1 and Wee1 Inhibitors with Olaparib Are Active in Olaparib Resistant Brca1 Proficient and Deficient Murine Ovarian Cells.

Michela Chiappa Federica Guffanti Martina Anselmi Monica LupiNicolò PaniniLisa Wiesmuller Giovanna Damia

Published in: Cancers (2022)

Olaparib-resistant cell lines were generated and displayed multiple mechanisms of resistance, which will be instrumental in selecting new possible therapeutic options for PARPi-resistant ovarian tumors.

Keyphrases

induced apoptosis
dna damage response
cell cycle arrest
signaling pathway