Direct next-generation sequencing analysis using endometrial liquid-based cytology specimens for rapid cancer genomic profiling.

Toshiaki AkahaneIkumi KitazonoYusuke KobayashiYukari Nishida-KiritaTomomi YamaguchiShintaro YanazumeKazuhiro TabataHiroaki KobayashiAkihide Tanimoto

Published in: Diagnostic cytopathology (2021)

The residual LBC specimens collected using endometrial cytology were verified to carry a high tumor fraction for NGS analysis and could serve as an alternate source for rapid molecular classification and diagnosis of endometrial cancers, as a routine process in a pathology laboratory.

Keyphrases

fine needle aspiration
ultrasound guided
endometrial cancer
high grade
copy number
papillary thyroid
machine learning
loop mediated isothermal amplification
deep learning
clinical practice
single cell
gene expression
ionic liquid
childhood cancer
single molecule
circulating tumor