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Weak Directing Group Steered Formal Oxidative [2+2+2]-Cyclization for Selective Benzannulation of Indoles.

Kiran R BettadapurRaja KapanaiahVeeranjaneyulu LankeKandikere Ramaiah Prabhu
Published in: The Journal of organic chemistry (2018)
A double C-H activation and double insertion process to achieve the synthesis benzo[e]indole frameworks has been disclosed. This type of benzannulation is directed by a trifluoromethylketone moiety, which is easy to install on the indole C3-position. Overall the reaction takes places as an oxidative cyclization of two alkynes with the C4-C5 position of indole.
Keyphrases
  • molecular dynamics
  • molecular dynamics simulations