A potential role of Sirtuin3 and its target enzyme activities in patients with ovarian endometrioma.

İslim KalelerAbdullah Serdar AcikgozAltay GezerEzel Uslu

Published in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2021)

Our results suggested that decreased levels of SIRT3 in endometrioma may be an important factor in the weakening of mitochondrial energy metabolism and antioxidant defense in endometriosis. We think that SIRT3 deficiency may be an important factor underlying the pathogenesis of endometriosis. More detailed studies are needed to reveal the relationship between SIRT3 and metabolism and oxidative stress in ovarian endometrioma.

Keyphrases

oxidative stress
ischemia reperfusion injury
diabetic rats
dna damage
induced apoptosis
genome wide
single cell
case control
innate immune
signaling pathway