AKAP12 promotes cancer stem cell-like phenotypes and activates STAT3 in colorectal cancer.
Ke LiXuan WuYuan LiTing-Ting HuWeifeng WangFrank J GonzalezWeiwei LiuPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)
This study suggests Colorectal CSCs overexpress AKAP12 and maintain stem cell characteristics through the AKAP12/PKC/STAT3 pathway. AKAP12 may be an important therapeutic target for blocking the development of colorectal cancer in the field of cancer stem cells.