Periostin-TGF-β feedforward loop contributes to tumour-stroma crosstalk in liver metastatic outgrowth of colorectal cancer.
Bin LiuTiantian WuBiyu LinXingxing LiuYingfu LiuGang SongChuannan FanGaoliang OuyangPublished in: British journal of cancer (2023)
POSTN and TGF-β1 cooperatively contribute to the tumour-stroma crosstalk by forming a supporting fibrotic microenvironment to promote liver metastasis of CRC cells via the POSTN/integrin/FAK/ERK/STAT3/TGF-β axis in tumour cells and TGF-β/Smad/POSTN signalling in activated HSCs.
Keyphrases
- transforming growth factor
- induced apoptosis
- cell cycle arrest
- epithelial mesenchymal transition
- signaling pathway
- cell proliferation
- small cell lung cancer
- stem cells
- squamous cell carcinoma
- endoplasmic reticulum stress
- pi k akt
- cell death
- oxidative stress
- idiopathic pulmonary fibrosis
- systemic sclerosis
- transcription factor
- cell migration