Cortisol-producing adenoma-related somatic mutations in unilateral primary aldosteronism with concurrent autonomous cortisol secretion: their prevalence and clinical characteristics.

Wan-Chen WuKang-Yung PengJin-Ying LuChieh-Kai ChanChih-Yuan WangFen-Yu TsengWei-Shiung YangYen-Hung LinPo-Chih LinTing-Chu ChenKuo-How HuangJeff S ChuehVin-Cent Wu

Published in: European journal of endocrinology (2022)

Our study showed that CPA-related mutations were detected in 36.7% of uPA/ACS adenomas. The presence of these mutations was associated with higher post-DST cortisol levels, larger adenoma sizes, and a high percentage of non-classical uPA. However, these mutations did not significantly affect the clinical and biochemical outcomes after adrenalectomy of uPA/ACS patients but they showed a better trend.

Keyphrases

acute coronary syndrome
end stage renal disease
newly diagnosed
chronic kidney disease
risk factors
peritoneal dialysis
prognostic factors
squamous cell carcinoma
radiation therapy
locally advanced