Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis.

Koen VenkenMatthias JarlborgTine DecruyCéline MortierCarolien VliegheElisabeth GilisAnn-Sophie De CraemerJulie CoudenysIsabelle CambréDevan FleuryAlexander KlimowiczFilip E Van den BoschAnne HoorensTriana LobatonSytze de RoockTim SparwasserGerald NaboznyPeggy Jacques Dirk Elewaut

Published in: Annals of the rheumatic diseases (2023)

These data point to profound differences in immune-regulation between Crohn's ileitis and peripheral arthritis. Whereas Tregs control ileitis they fail to dampen joint inflammation. Synovial resident Tregs are particularly maladapted to chronic TNF exposure.

Keyphrases

regulatory t cells
rheumatoid arthritis
oxidative stress
disease activity
dendritic cells
ankylosing spondylitis
intellectual disability
electronic health record
big data
data analysis
drug induced
chemotherapy induced