Small AAAs: Recommendations for Rodent Model Research for the Identification of Novel Therapeutics.
Jonathan GolledgeHong S Lu (吕红)John A CurciPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
The aortic adventitial elastase oral β-aminopropionitrile model has many strengths including simulating human AAA pathology and modeling prolonged aneurysm growth. The Ang II (angiotensin II) model performed less well as it better simulates acute aortic syndrome than AAA. The elastase plus TGFβ (transforming growth factor-β) blocking antibody model displays a high rupture rate, making prolonged monitoring of AAA growth not feasible. The elastase perfusion and calcium chloride models both display limited AAA growth.
Keyphrases
- angiotensin ii
- transforming growth factor
- epithelial mesenchymal transition
- left ventricular
- coronary artery
- aortic dissection
- pulmonary artery
- angiotensin converting enzyme
- small molecule
- vascular smooth muscle cells
- magnetic resonance
- intensive care unit
- clinical practice
- hepatitis b virus
- mechanical ventilation
- extracorporeal membrane oxygenation