High phosphate impairs arterial endothelial function through AMPK-related pathways in mouse resistance arteries.

Weipeng HuShan JiangYixin LiaoJinhong LiFang DongJie GuoXiaohua WangLingyan FeiYu CuiXiaoqiu RenNan XuLiang ZhaoLimeng ChenYali ZhengLingli LiAndreas PatzakPontus B PerssonZhihua ZhengEn-Yin Lai

Published in: Acta physiologica (Oxford, England) (2020)

HP impairs endothelial function by reducing NO bioavailability via decreasing eNOS activity and increasing mitochondrial ROS, in which the AMPK-related signalling pathways may play a key role.

Keyphrases

skeletal muscle
oxidative stress
dna damage
cell death
endothelial cells
protein kinase
nitric oxide synthase