Piezo1-Mediated Neurogenic Inflammatory Cascade Exacerbates Ventricular Remodeling After Myocardial Infarction.

Meiyan SunSui MaoChao WuXiaoyong ZhaoChengxiao GuoJun HuShijin XuFen ZhengGuo-Qing Zhu Hui Tao Shufang He Ji Hu Ye Zhang

Published in: Circulation (2024)

Our findings point to a critical role for Piezo1 in ventricular remodeling at 4 weeks after MI and reveal a neurogenic inflammatory cascade as a previously unknown facet of the neuronal immune signaling axis underlying mechanotransduction.

Keyphrases

spinal cord injury
heart failure
left ventricular
oxidative stress
catheter ablation
genome wide
single cell
gestational age
dna methylation