Risk factors for histological progression of non-alcoholic steatohepatitis analyzed from repeated biopsy cases.
Kana DaijoTakashi NakaharaYuki InagakiMaiko NanbaTomokazu KawaokaShinsuke UchikawaKenichiro KodamaKazuki OhyaKei MorioHatsue FujinoAtsushi OnoEisuke MurakamiMasami YamauchiTomokazu KawaokaDaiki MikiMasataka TsugeAkira HiramatsuC Nelson HayesMichio ImamuraHiroshi AikataHidenori OchiKazuaki ChayamaPublished in: Journal of gastroenterology and hepatology (2020)
In this study, we clarified the serum ALT level and the clinical significance of HbA1c to evaluate the progression of fibrosis in Japanese NASH patients. Furthermore, the tumor necrosis factor SNP was more likely to be involved in the response than PNPLA3 SNP. By simultaneously evaluating three factors, it is possible to estimate the risk of histological progression more accurately.