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Stepwise oral immunotherapy for 10 days in an egg-white allergy mouse model did not ameliorate the severity of allergy but induced the production of allergen-specific IgA.

Akihiro MaetaRisako KatahiraMarin MatsushimaHaruka OnishiYu NakamuraKyoko Takahashi
Published in: Bioscience, biotechnology, and biochemistry (2018)
We examined whether the stepwise oral immunotherapy (OIT) for 10 days ameliorates the severity of allergy and the biomarkers in an allergy mouse model. The OIT could not protect anaphylaxis symptoms after allergen challenges but promote the production of antibodies, especially allergen-specific IgA. It was suggested that this OIT influenced the function of immuno response against the allergen. Abbreviations: EW: egg white; IFC: intraperitoneal food challenge; IFN-γ: interferon-γ; IL: interleukin; OVA: ovalbumin; OM: ovomucoid; OFC: oral food challenge; OIT: oral immunotherapy.
Keyphrases
  • mouse model
  • allergic rhinitis
  • atopic dermatitis
  • dendritic cells
  • infectious diseases
  • immune response
  • human health
  • endothelial cells
  • depressive symptoms
  • drug induced