Gene Transfer Potential of Outer Membrane Vesicles of Gram-Negative Bacteria.
Federica Dell'AnnunziataVeronica FollieroRosa GiuglianoAnna De FilippisCristina SantarcangeloViviana IzzoMaria DagliaMassimiliano GaldieroCarla Renata ArciolaGianluigi FranciPublished in: International journal of molecular sciences (2021)
The increasing spread of multidrug-resistant pathogenic bacteria is one of the major threats to public health worldwide. Bacteria can acquire antibiotic resistance and virulence genes through horizontal gene transfer (HGT). A novel horizontal gene transfer mechanism mediated by outer membrane vesicles (OMVs) has been recently identified. OMVs are rounded nanostructures released during their growth by Gram-negative bacteria. Biologically active toxins and virulence factors are often entrapped within these vesicles that behave as molecular carriers. Recently, OMVs have been reported to contain DNA molecules, but little is known about the vesicle packaging, release, and transfer mechanisms. The present review highlights the role of OMVs in HGT processes in Gram-negative bacteria.
Keyphrases
- genome wide
- public health
- genome wide identification
- multidrug resistant
- copy number
- escherichia coli
- pseudomonas aeruginosa
- staphylococcus aureus
- genome wide analysis
- single molecule
- electron transfer
- drug resistant
- acinetobacter baumannii
- circulating tumor
- klebsiella pneumoniae
- human health
- circulating tumor cells
- nucleic acid