The Active Metabolite of Warfarin (3'-Hydroxywarfarin) and Correlation with INR, Warfarin and Drug Weekly Dosage in Patients under Oral Anticoagulant Therapy: A Pharmacogenetics Study.

Donato GemmatiFrancesco BuriniAnna TalaricoMatteo FabbriCesare BertoccoMarco ViglianoStefano MoratelliAntonio CuneoMaria Luisa SerinoFrancesco Maria AvatoVeronica TisatoRosa Maria Gaudio

Published in: PloS one (2016)

Our results overall suggest that 3'-hydroxywarfarin monitoring could be of great advantage in INR monitoring respect to classical warfarin assessment showing significant contribution also in multivariate analysis. Therefore, additional active metabolites should be recognized and investigated as novel useful indicators.

Keyphrases

atrial fibrillation
venous thromboembolism
direct oral anticoagulants
oral anticoagulants
ejection fraction
newly diagnosed
prognostic factors
ms ms
emergency department
patient reported outcomes
adverse drug
patient reported
drug induced
electronic health record
clinical evaluation