Fractal motor activity regulation and sex differences in preclinical Alzheimer's disease pathology.

Lei GaoPeng LiArlen GabaErik MusiekYo-El S JuKun Hu

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2021)

Changes in daytime FMAR from actigraphy appear to be present in women early in preclinical AD. This may be a combination of earlier pathology changes in females reflected in daytime FMAR, and a relatively underpowered male group. Further studies are warranted to test FMAR as an early noncognitive physiological biomarker that precedes the onset of cognitive symptoms.

Keyphrases

sleep quality
obstructive sleep apnea
cell therapy
polycystic ovary syndrome
depressive symptoms
cognitive decline
case control
stem cells
metabolic syndrome
insulin resistance
breast cancer risk
mild cognitive impairment