Somatic Mutation Profiling of Intrahepatic Cholangiocarcinoma: Comparison between Primary and Metastasis Tumor Tissues.
Shi-Feng XuYuan GuoXin ZhangXiao-Dan ZhuNing FanZhi-Lei ZhangGui-Bing RenWei RaoYun-Jin ZangPublished in: Journal of oncology (2020)
In this study, the identification of two meaningful mutated genes, BRAF and LRP1B, highly mutated immune gene harbored by primary ICC patients. Both in PSs and MSs, no patients with MSI-H showed PDL1 positive. The Notch pathway had more alteration genes in patients with MSI-H. And the enrichment of the platinum drug resistance pathway in MSs might offer reference for the novel therapeutic strategy of ICC.
Keyphrases
- genome wide
- end stage renal disease
- genome wide identification
- bioinformatics analysis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- copy number
- gene expression
- peritoneal dialysis
- prognostic factors
- wild type
- genome wide analysis
- cell proliferation
- patient reported outcomes
- single cell
- transcription factor