Epigenetic age acceleration is associated with oligodendrocyte proportions in MSA and control brain tissue.
Megha MurthyGemma ShirebyYasuo MikiEmmanuelle ViréTammaryn LashleyThomas T WarnerJonathan MillConceicao BettencourtPublished in: Neuropathology and applied neurobiology (2023)
Our findings show that oligodendrocyte proportions positively influence epigenetic age acceleration across brain regions and highlight the need to further investigate this in ageing and neurodegeneration.