Epigenetic Regulation in Schizophrenia: Focus on Methylation and Histone Modifications in Human Studies.
Natasha DelphinCaitlin AustLyn R GriffithsFrancesca FernandezPublished in: Genes (2024)
Despite extensive research over the last few decades, the etiology of schizophrenia (SZ) remains unclear. SZ is a pathological disorder that is highly debilitating and deeply affects the lifestyle and minds of those affected. Several factors (one or in combination) have been reported as contributors to SZ pathogenesis, including neurodevelopmental, environmental, genetic and epigenetic factors. Deoxyribonucleic acid (DNA) methylation and post-translational modification (PTM) of histone proteins are potentially contributing epigenetic processes involved in transcriptional activity, chromatin folding, cell division and apoptotic processes, and DNA damage and repair. After establishing a summary of epigenetic processes in the context of schizophrenia, this review aims to highlight the current understanding of the role of DNA methylation and histone PTMs in this disorder and their potential roles in schizophrenia pathophysiology and pathogenesis.
Keyphrases
- dna methylation
- genome wide
- bipolar disorder
- gene expression
- dna damage
- copy number
- endothelial cells
- oxidative stress
- metabolic syndrome
- cell death
- cardiovascular disease
- dna repair
- single cell
- stem cells
- single molecule
- physical activity
- type diabetes
- molecular dynamics simulations
- anti inflammatory
- mesenchymal stem cells
- cell therapy
- weight loss
- bone marrow
- heat stress