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The Mechanism Study of Common Flavonoids on Antiglioma Based on Network Pharmacology and Molecular Docking.

Taiping LiYong XiaoZhen WangHong XiaoHongyi Liu
Published in: Evidence-based complementary and alternative medicine : eCAM (2022)
The findings of this study indicated that selected active flavonoid compounds might play therapeutic roles in glioma mainly through the PI3K-Akt signaling pathway. Moreover, EGCG had the potential antiglioma activity by targeting MAPK1 and HSP90AA1.
Keyphrases
  • molecular docking
  • signaling pathway
  • pi k akt
  • oxidative stress
  • molecular dynamics simulations
  • cell proliferation
  • climate change