Limited Diagnostic Utility of Chromogranin A Measurements in Workup of Neuroendocrine Tumors.

Jonas BaekdalJesper KroghMarianne KlosePernille HolmagerSeppo W LangerPeter OturaiAndreas KjaerBirgitte FederspielLinda HilstedJens F RehfeldUlrich KniggeMikkel Andreassen

Published in: Diagnostics (Basel, Switzerland) (2020)

Our data do not support using measurement of CgA for screening when NET is suspected since the PPV was rather low. PPI treatment is a common cause of increased CgA concentrations and should always be discontinued before CgA measurement. PIA of CgA could be a way of excluding NET when suspicion is based primarily on elevated CgA.

Keyphrases

neuroendocrine tumors
electronic health record
pulmonary embolism
big data
machine learning
artificial intelligence
deep learning
data analysis