Clinical significance of peripheral T-cell receptor repertoire profiling and individualized nomograms in patients with gastrointestinal cancer treated with anti-programmed death 1 antibody.

Jing WuYiyi YuShilong ZhangPengfei ZhangShan YuWei LiYan WangQian LiBinbin LuLimeng ChenChonglin LuoHaixiang PengTianshu LiuYuehong Cui

Published in: Translational gastroenterology and hepatology (2024)

High DE50 scores were predictive of a favorable response and longer PFS to anti-PD-1 treatment in GIC patients. The nomogram based on TCR repertoire profiling was a reliable and practical tool, which could provide risk assessment and clinical decision-making for individualized treatment of patients.

Keyphrases

risk assessment
newly diagnosed
end stage renal disease
ejection fraction
chronic kidney disease
single cell
papillary thyroid
prognostic factors
regulatory t cells
lymph node metastasis
heavy metals
patient reported outcomes
high throughput sequencing
combination therapy
binding protein