Characterization of PCLO Gene in Amazonian Native American Populations.
Amanda de Nazaré Cohen-PaesDarlen Cardoso de CarvalhoLucas Favacho PastanaElizabeth Ayres Fragoso DobbinFabiano Cordeiro MoreiraTatiane Piedade de SouzaMarianne Rodrigues FernandesDiana Feio da Veiga Borges LealRoberta Borges Andrade de SáAngélica Leite de AlcântaraJoão Farias GuerreiroÂndrea Kely Campos Ribeiro Dos SantosSidney Emanuel Batista Dos SantosPaulo Pimentel de AssumpçãoNey Pereira Carneiro Dos SantosPublished in: Genes (2022)
Genetic variations in PCLO have been associated with different pathologies in global literature, but there are no data regarding this gene in Native American populations. The Amazonian Native American populations have lower genetic diversity and are more different from other continental groups. We investigated 18 genetic variants in the PCLO gene in Amazonian indigenous and compared our results with the ones found in global populations, which were publicly available in the 1000 Genomes Project, gnmAD and ABraOM databases. The results demonstrated that the variants of the PCLO , especially rs17156844, rs550369696, rs61741659 and rs2877, have a significantly higher frequency in Amerindian populations in comparison with other continental populations. These data outline the singular genetic profile of the Native American population from the Brazilian Amazon region.