Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.

Matthew ZimmermanStacey L McDonaldHsin-Pin Ho-LiangPatrick PorubskyQuyen NguyenCameron W PharrAndrew J PerkowskiRobert SmithFrank J SchoenenBen S GoldDavid ZhangCarl F NathanVéronique DartoisJeffrey Aube

Published in: The Journal of antibiotics (2019)

A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.

Keyphrases

dna binding
transcription factor