Primary alterations during the development of hidradenitis suppurativa.
Zsolt DajnokiO SomogyiB MedgyesiA JeneiL SzabóK GáspárZ HendrikP GergelyD ImreS PóliskaD TörőcsikChristos C ZouboulisE P PrensA KapitányA SzegediPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2021)
Our findings that non-lesional HS epidermal keratinocytes produce not only AMPs and IL-1β but also high levels of TNF-α and IL-23 confirm the driver role of keratinocytes in HS pathogenesis and highlight the possible role of keratinocytes in the transformation of non-inflammatory Th17 cells (of healthy AGR skin) into inflammatory cells (of HS) via the production of these mediators. The fact that epidermal TNF-α and IL-23 appear also in non-lesional HS seems to prove these cytokines as excellent therapeutic targets.