Elucidating Epigenetic Regulation by Identifying Functional cis-Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage.

Marcella van HoolwerffPaula I MetselaarMargo TuerlingsH Eka D SuchimanNico LakenbergYolande F M RamosDavy CatsRob G H H NelissenDemiën BroekhuisHailiang MeiRodrigo Coutinho de Almeida Ingrid Meulenbelt

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

By applying an improved detection strategy, robustly differentially expressed lncRNAs in OA cartilage were detected. Integration of these lncRNAs with differential mRNA expression levels in the same samples provided insight into their regulatory networks. Our data indicates that intergenic and antisense lncRNAs play an important role in regulating the pathophysiology of OA.

Keyphrases

network analysis
genome wide identification
genome wide analysis
knee osteoarthritis
transcription factor
electronic health record
big data
loop mediated isothermal amplification
machine learning
real time pcr
deep learning
data analysis
sensitive detection