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Dual Inhibition of the Wnt Inhibitors DKK1 and Sclerostin Promotes Fracture Healing and Increases the Density and Strength of Uninjured BoneAn Experimental Study in Nonhuman Primates.

Monica FlorioPaul J KostenuikMarina StolinaFranklin J AsuncionMario GrisantiHua Zhu KeMichael S Ominsky
Published in: The Journal of bone and joint surgery. American volume (2023)
Combination therapy with antibodies against sclerostin and DKK1 may offer a promising therapeutic strategy for both fracture treatment and fracture prevention.
Keyphrases
  • combination therapy
  • hip fracture
  • cell proliferation