Dual Inhibition of the Wnt Inhibitors DKK1 and Sclerostin Promotes Fracture Healing and Increases the Density and Strength of Uninjured BoneAn Experimental Study in Nonhuman Primates.
Monica FlorioPaul J KostenuikMarina StolinaFranklin J AsuncionMario GrisantiHua Zhu KeMichael S OminskyPublished in: The Journal of bone and joint surgery. American volume (2023)
Combination therapy with antibodies against sclerostin and DKK1 may offer a promising therapeutic strategy for both fracture treatment and fracture prevention.