Natalizumab Treatment Induces Proinflammatory CD4 T Cells Preferentially in the Integrin β7+ Compartment.

Mélanie Nguyen KyAdrien DuranIris Hasantari Agnès BruMathilde DeloireBruno BrochetAurélie RuetNathalie Schmitt

Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)

Our study shows that circulating integrin β7+ memory CD4 T cells of patients with relapsing-remitting MS under natalizumab are enriched in proinflammatory cells supporting the hypothesis that integrin β7+ memory CD4 T cells could play a pathogenic role in the disease rebound observed at natalizumab discontinuation.

Keyphrases

multiple sclerosis
induced apoptosis
working memory
cell adhesion
cell migration
ms ms
smoking cessation